How obesity influence psoriasis severity in developing countries

Psoriasis is a common chronic inflammatory skin disease with complex pathogenesis consisting of genetic component, immune dysfunction, and environmental factors. It associated numerous comorbidities including psoriatic arthritis, cardiovascular disease, metabolic syndrome, obesity. The dietary habits in industrialized nations promote high-fat, high-salt, high-sugar diets excess caloric intake resulting an obesity epidemic. Meta-analyses have shown that (1) genetically higher BMI increased the odds psoriasis occurrence; (2) incidence prevalence as well severity; (3) lower efficacy to anti-TNF agents may predict biologic treatment discontinuation; (4) weight loss through diet physical exercise improve pre-existing psoriasis. Obesity one major public health concerns due its upward trend both developing developed countries. In countries, consequence not only affects but also creates burden on individual national healthcare budgets. overweight countries increasing faster than world average. This fast-paced growth has been accompanied by notable increases non-communicable diseases (NCDs). While gradually where NCD yet implement. If proper program implement right time, severity will increase